Phylogenomics

Phylogenomics: Foundations, Methods, and Pathogen Analysis traces the field of phylogenomics from its groundwork to its most recent advances. It equips researchers to plan and carry out their own studies by covering both the underlying concepts and the practical techniques behind them.

The opening chapters examine how phylogenomics is used to classify organisms and pathogens, and they cover phylogenomic networks, the phylogenomic study of virus virulence, and the analysis of ancient DNA. The central section concentrates on methods, with detailed explanations and step-by-step instructions for genome assembly and annotation, horizontal gene transfer studies, Bayesian evaluation, phylogenetic tree construction, the modeling of microbial evolution, and molecular epidemiology.

The final section presents worked examples of phylogenomic analysis in medically important bacteria and viruses. These include Yersinia pestis, Salmonella, Shigella, Vibrio cholerae, and Mycobacterium tuberculosis, along with several others. The chapters are contributed by experts from several countries, and the book pairs a broad introduction to phylogenetics and phylogenomics with the algorithms and methodologies used to study disease-causing microorganisms.